Candidate Review

CAND-P1-LEAD-01

needs review

TCE_trispecific · loading real scores from the NOVA-3 API…

3D Structure · predicted foldESMFold

⬡Press "Build review" to fold and render the candidate.

Very high ≥90 Confident 70–90 Low 50–70 Very low <50

Sequence Liability MapCDR-shaded · liabilities highlighted

Fold a candidate to see its annotated sequence.

CDR region NG deamidation DG isomerization free cysteine Met oxidation N-glycosylation

Scorecardcomputed estimates · reproducible

≥75 ready 55–74 acceptable <55 flagged all values are in-silico estimates, not measured

Design score

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Developability

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Humanness

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Theoretical pI

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Binding · limiting arm

—literature estimate

Module-anchored estimate — not measured, not de-novo predicted. Wet-lab SPR/BLI required before any binding claim.

This is a pre-wet-lab assessment. Structure confidence (pLDDT) is from a single-chain fold and is not interface confidence; binding is a literature-anchored estimate. The review ranks what to test first — it does not replace the assay.